G1T38: Experimental Treatment for Epidermal Growth Factor Receptor mutant (EGFRm) Non-Small Cell Lung Cancer (NSCLC)
Scientific rationale and therapeutic potential
G1T38 is a potent and selective oral CDK4/6 inhibitor designed to block the growth of cancer cells and induce tumor-cell death when combined with other anti-cancer agents, such as Tagrisso®. G1T38 has the potential to be best-in-class versus other oral CDK4/6 inhibitors.
Preclinical and clinical results (see: Publications)
- published preclinical data demonstrating G1T38 is more potent and less toxic than other oral CDK4/6 inhibitors in development;
- this is the first clinical trial of G1T38 in EGFRm NSCLC.
G1 is recruiting patients for a Phase 1b/2 trial in EGFRm NSCLC